Mitochondrial DNA 4977-base pair common deletion in blood leukocytes and melanoma risk
نویسندگان
چکیده
منابع مشابه
Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke
BACKGROUND Coronary artery disease is associated with a common mitochondrial DNA alteration, a 4977 bp deletion (mtDNA4977). The role of mtDNA4977 in ischemic stroke is unknown. METHODS Real-time quantitative PCR was performed to quantify total mtDNA and mtDNA4977 in leukocytes in 283 ischemic stroke cases and 135 controls. Ratios of mtDNA4977 to total-mtDNA and total-mtDNA to nuclear-DNA wer...
متن کاملCommon 4977 bp deletion and novel alterations in mitochondrial DNA in Vietnamese patients with breast cancer
Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis and ageing. The mtDNA 4977 bp deletion is one of the most frequently observed mtDNA mutations in human tissues and may play a role in breast cancer (BC). The aim of this study was to investigate the frequency of mtDNA 4977 bp deletion in BC tissue and its association with clinical factors. We determined the presence of...
متن کاملMitochondrial DNA content and 4977 bp deletion in unfertilized oocytes.
Previous studies analysing the incidences of mitochondrial DNA (mtDNA) deletions and mtDNA content in unfertilized oocytes in relation to donors' age have been controversial. The objective of the study was to compare these two parameters in unfertilized oocytes and relate them to the donors' age. Fifty-two women donated 155 unfertilized metaphase II (MII) oocytes. The incidence of 4977 bp delet...
متن کاملMitochondrial DNA 4977 bp deletion is a common phenomenon in hair and increases with age.
Mitochondrial DNA (mtDNA) is believed to be particularly susceptible to oxidative damage during aging, resulting in mtDNA point mutations, duplications, and deletions. Although mtDNA deletions have been reported in various human tissues, e.g., the brain, heart, and skeletal muscle, little is known about the occurrence in hair. Therefore, we screened for the presence of mtDNA 13162 bp, 10422 bp,...
متن کاملMitochondrial DNA 4977 BP deletion mutations in lung carcinoma.
BACKGROUND The most common and also the most often assayed mtDNA deletion mutation, degrees mtDNA 4,977 sub has been demonstrated in various types of human cancer. However, knowledge about degrees mtDNA 4,977 in lung carcinoma is poor. AIM To study the 4,977 bp deletions of mitochondrial DNA ( degrees mtDNA 4,977) in lung cancer, adjacent histologically normal and normal lung tissue and its p...
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ژورنال
عنوان ژورنال: Pigment Cell & Melanoma Research
سال: 2016
ISSN: 1755-1471
DOI: 10.1111/pcmr.12474